Clomid Comprimé

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Clomid Comprimé overall incidence of reported congenital anomalies from pregnancies associated with maternal Clomid ingestion during clinical studies was within the range of that reported for the general population. Indications and Usage for Clomid Clomid is indicated for the treatment of ovulatory dysfunction in women desiring pregnancy. Impediments to achieving pregnancy must be excluded or adequately treated before beginning Clomid therapy.

Ovarian Hyperstimulation Syndromeamenorrhea-galactorrhea syndrome, psychogenic amenorrhea, post-oral-contraceptive amenorrhea, and certain cases of secondary amenorrhea of undetermined etiology. Clomid Comprimé timed coitus in relationship to ovulation is important. A basal body temperature graph or other appropriate tests may help the patient and her physician determine if ovulation occurred. Once ovulation has been established, Clomid Comprimé, each course of Clomid should be started on or Clomid Comprimé the 5th day of the cycle.

Long-term cyclic therapy is not recommended beyond a total of about six cycles including three ovulatory cycles. Clomid Comprimé is indicated only in patients with demonstrated ovulatory dysfunction who meet the conditions described below: Patients who are Clomid Comprimé pregnant.

Clomid Comprimé Patients without ovarian cysts. Clomid should not be used in patients with ovarian enlargement except those with polycystic ovary syndrome. Pelvic examination is necessary prior to the first and each subsequent course of Clomid treatment.

Patients without abnormal vaginal bleeding. If abnormal vaginal bleeding is present, the patient should be carefully evaluated to ensure that neoplastic lesions are not present. Patients with normal liver function. In addition, patients selected for Clomid therapy should be evaluated in regard to the following: Patients should have adequate levels of endogenous estrogen as estimated from vaginal smears, Clomid Comprimé, endometrial biopsy, assay of urinary estrogen, or from bleeding in response to progesterone.

Reduced estrogen levels, while less favorable, Clomid Comprimé not preclude successful therapy. Primary Pituitary or Ovarian Failure.

Clomid therapy cannot be expected to substitute for specific treatment Clomid Comprimé other causes of ovulatory failure. Endometriosis and Endometrial Carcinoma. The incidence of endometriosis and endometrial carcinoma increases with age as does the incidence of Clomid Comprimé disorders.

Endometrial biopsy should always be performed prior to Clomid therapy in this population. Clomid Comprimé Impediments to Pregnancy. Impediments to pregnancy can include thyroid disorders, Clomid Comprimé, adrenal disorders, hyperprolactinemia, and male factor infertility.

Caution should be exercised when using Clomid in patients with uterine fibroids due to the potential for further enlargement of the fibroids. There are no adequate or well-controlled studies that demonstrate the effectiveness of Clomid in the treatment of male infertility. In addition, testicular tumors and gynecomastia have been reported in males using clomiphene. The cause and effect relationship between reports of testicular tumors and the administration of Clomid is not known.

Although the medical literature suggests various methods, there is no universally accepted standard regimen for combined therapy ie, Clomid in conjunction with other ovulation-inducing drugs.

Similarly, there is no standard Clomid regimen for ovulation induction in in vitro fertilization programs to produce ova for fertilization and reintroduction. Therefore, Clomid is not recommended for these uses. Contraindications Hypersensitivity Clomid is contraindicated in patients with a known hypersensitivity or allergy to clomiphene citrate or to any of its ingredients. Pregnancy Pregnancy Category X Clomid use in pregnant women is contraindicated, as Clomid does not offer benefit in this population.

Available human Clomid Comprimé do Clomid Comprimé suggest an increased risk for congenital anomalies above the background population risk when used as indicated. However, animal reproductive toxicology studies showed increased embryo-fetal loss and structural malformations in offspring. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential risks to the fetus.

Warnings Visual Symptoms Patients should be advised that blurring or other visual symptoms such as spots or flashes scintillating scotomata Clomid Comprimé occasionally occur during therapy with Clomid.

These visual symptoms increase in incidence with increasing total dose or therapy duration.

Dans quels cas le médicament CLOMID est-il utilisé ?

These visual disturbances are usually reversible; however, cases of prolonged visual disturbance have been reported with some occurring after Clomid discontinuation. The visual disturbances may be irreversible, especially with increased dosage or duration of therapy, Clomid Comprimé. Patients should be warned that these visual symptoms may render such activities as driving a car or operating machinery more hazardous than usual, particularly under conditions of variable lighting.

These visual symptoms appear to be due to intensification and prolongation of afterimages. Symptoms often first appear or are accentuated with exposure to a brightly lit environment.

While measured visual acuity usually has not been affected, a Clomid Comprimé patient taking mg Clomid daily developed visual blurring on the 7th day of treatment, which progressed to severe diminution of visual acuity by the 10th day. No other abnormality was found, and the visual acuity returned to normal on the 3rd day after treatment was stopped. Ophthalmologically definable scotomata and retinal cell function electroretinographic changes have also been reported.

A patient treated during clinical studies developed phosphenes and scotomata during prolonged Clomid administration, which disappeared by the 32nd day after stopping therapy. While the etiology of these visual symptoms is not yet understood, patients with any visual symptoms should discontinue treatment and have a complete ophthalmological evaluation carried out promptly. Ovarian Hyperstimulation Syndrome The ovarian hyperstimulation syndrome OHSS has been reported to occur in patients receiving clomiphene citrate therapy for ovulation induction.

OHSS may progress rapidly within 24 hours to several days and become a serious medical disorder. In some cases, OHSS occurred following cyclic use of clomiphene citrate therapy or when clomiphene citrate was used in combination with gonadotropins.

Transient liver function Clomid Comprimé abnormalities suggestive of hepatic dysfunction, which may be accompanied by morphologic changes on liver biopsy, have been reported in association with OHSS. OHSS is a medical event distinct from uncomplicated ovarian enlargement. The clinical signs of this syndrome in severe cases can include gross ovarian enlargement, gastrointestinal symptoms, ascites, dyspnea, oliguria, and pleural effusion.

In addition, Clomid Comprimé following symptoms have been reported in association with this syndrome: The early warning signs of OHSS are abdominal pain and distention, nausea, vomiting, diarrhea, Clomid Comprimé, and weight gain.

Elevated urinary steroid levels, varying degrees of electrolyte imbalance, Clomid Comprimé, hypovolemia, hemoconcentration, and hypoproteinemia may occur. Death due to hypovolemic shock, hemoconcentration, Clomid Comprimé, or thromboembolism has occurred.

Due to fragility of enlarged ovaries in severe cases, abdominal and pelvic examination should be performed very cautiously. If conception results, Clomid Comprimé, rapid progression to the severe form of the syndrome may occur, Clomid Comprimé. To minimize the hazard associated with occasional abnormal ovarian enlargement associated with Clomid therapy, Clomid Comprimé, the lowest dose consistent with expected clinical results should be used.

Maximal enlargement of the ovary, Clomid Comprimé, whether physiologic Clomid Comprimé abnormal, may not occur until several days after discontinuation of the recommended dose of Clomid. Some patients with polycystic ovary syndrome who are unusually sensitive to gonadotropin may have an exaggerated response to usual doses of Clomid, Clomid Comprimé.

If enlargement of the ovary occurs, additional Clomid therapy should not be given until the ovaries have returned to pretreatment size, and the dosage or duration of the next course should be reduced, Clomid Comprimé. Ovarian enlargement and cyst formation associated with Clomid therapy usually regresses spontaneously within a few days or weeks after discontinuing treatment.

The potential benefit of subsequent Clomid therapy in these cases should exceed Clomid Comprimé risk. Unless surgical indication for laparotomy exists, such cystic enlargement should always be managed conservatively.

Acheter Clomid

A causal relationship between ovarian hyperstimulation and ovarian cancer has not been determined. However, because a correlation between ovarian cancer and nulliparity, infertility, and age has been suggested, if ovarian cysts do not regress spontaneously, a thorough evaluation should be performed to rule Clomid Comprimé the presence of ovarian neoplasia.

Precautions General Careful attention should be given to the selection of candidates for Clomid therapy. Information for Patients The purpose and risks of Clomid therapy should be presented to Clomid Comprimé patient before starting treatment. It should be emphasized that the goal of Clomid therapy is ovulation for subsequent pregnancy.

The physician Clomid Comprimé counsel the patient with special regard to the following potential risks: Visual Symptoms Advise that blurring or other visual symptoms occasionally may occur during or shortly after Clomid therapy. It should be made clear Clomid Comprimé the patient that, in some instances, visual disturbances may be prolonged, and possibly irreversible, especially with increased dosage or duration of therapy.

Warn that visual symptoms may render such activities as driving a car or operating machinery more hazardous than usual, particularly under conditions of variable lighting see WARNINGS. The patient should be instructed to inform the physician whenever any unusual visual symptoms occur. If the patient has any visual symptoms, treatment should be discontinued and complete ophthalmologic evaluation performed.

To minimize the risks associated with ovarian enlargement, the patient should be instructed to inform the physician of any abdominal or pelvic pain, weight gain, discomfort, or distention after taking Clomid see WARNINGS. Metabolism Clomid Comprimé Cases of hypertriglyceridemia have been reported, Clomid Comprimé. Multiple Pregnancy Inform the patient that there is an increased chance of multiple pregnancy, including bilateral Clomid Comprimé pregnancy and coexisting tubal and intrauterine pregnancy, when conception occurs in relation to Clomid therapy.

The potential complications and hazards of multiple pregnancy should be explained, Clomid Comprimé.

Spontaneous Abortion and Congenital Anomalies Inform the patient that the available data suggest no increase in the rates of spontaneous abortion miscarriage or congenital anomalies with maternal Clomid use compared to rates in the general population. During clinical investigation, Clomid Comprimé, the experience from patients with known pregnancy outcome Table 1 shows a spontaneous abortion rate of Among the birth anomalies Clomid Comprimé reported as individual cases since commercial availability of Clomid, the proportion of neural tube defects has been Clomid Comprimé among pregnancies associated with ovulation induced by Clomid, but this has not been supported by data from population-based studies, Clomid Comprimé.

Drug Interactions Drug interactions with Clomid have not been documented, Clomid Comprimé. Carcinogenesis, Mutagenesis, Impairment of Clomid Comprimé Long-term toxicity studies in animals have not been performed to evaluate the carcinogenic or mutagenic potential of clomiphene citrate.

Oral administration of Clomid to male rats at doses of 0. Oral doses of 0. Clomid use in pregnant women is contraindicated, as Clomid treatment does not offer benefit in this population. Available human data do not suggest an increased risk for congenital anomalies above the background population risk. Patients should be evaluated carefully to exclude ovarian enlargement or ovarian cyst formation between each treatment cycle.

The next course of Clomid therapy should be delayed until these conditions have been excluded. Human data The available human data from epidemiologic studies do not show any apparent cause and effect relationship between clomiphene citrate periconceptual exposure and an increased risk of overall birth defects, or Clomid Comprimé specific anomaly.

However, due to the small number of cases of congenital anomalies occurring in clomiphene citrate treated women, these epidemiologic studies were only able to rule out large differences in risk.

The studies did not consider factors associated with female subfertility and were unable to adjust for other important confounders.

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