Mefenamic acid Par Mail
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Results From all results obtained in this study, it could be seen that the dissolution test method of PPRC can be choosen for dissolution test of both capsule and caplet mefenamic acid dosage forms. To obtain this required percentage faster, the condition related to the dissolution apparatus could be modified, Mefenamic acid Par Mail, i.
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If the apparatus condition will be maintained the same not modifiedMefenamic acid Par Mail, the requirement can be changed instead, for example: Other alternative which is also possible to be applied is by using surfactant which can increase the solubility of the drug significantly in physiological pH range, such as cetyl-trimethylammonium-bromide CTAB or cetrimide. Some studies have found that the addition of cetrimide could raise the solubility and dissolution rate of mefenamic acid to a far higher extent than those resulted by other surfactants, such as Tween 80 and SLS [ 1213 ].
In all cases, in vitro-in vivo correlation should ideally be tested in order to obtain Mefenamic acid Par Mail prediction of in vivo performance of the drug. In all of the dissolution mediums, Mefenamic acid Par Mail, the highest dissolution rate was achieved by capsule dosage form.
USP dissolution requirement for capsule dosage form could not be applied for the requirement of caplet product. All other chemicals and reagents were of analytical grades. Samples were withdrawn at 1, 2, 3, 4, 8, 12, 24 and 48 h.
Before taking mefenamic acid
Dissolution test All dissolution tests used 12 units of each drug product, except for those in FaSSIF Mefenamic acid Par Mail only 4 units. In all of the experiments, 5 mL of dissolution medium samples were withdrawn at 15, 30, 45, 60, Mefenamic acid Par Mail, 90, and min. The replacement with an equal volume of the fresh medium to maintain a constant total dissolution medium volume was carried out after each time of sampling.
Samples taken from the dissolution medium were filtered immediately, diluted with corresponding dissolution medium if necessary and assayed by UV spectrophotometry method. Cumulative percentages of the drug dissolved from the tested products were calculated by taking into account the samples withdrawn previously.
Drug assay Drug concentrations in the solubility and dissolution tests were determined by UV spectrophotometry at the wavelength of nm for samples taken from USP and PPRC Mefenamic acid Par Mail and at nm for those from biorelevant medium, in accordance with the maximum wavelength of mefenamic acid in each dissolution mediums. The assay was verified before it was used for the drug assay.
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References [1] Sweetman SC. Martindale The Complete Drug Reference. World J Pharm Pharm Sci. United States Pharmacopeia United States Pharmacopoeial Convention; Chemical Industry Press; Kementrian Kesehatan Republik Indonesia; Development of dissolution medium for poorly water soluble drug mefenamic acid.
Introduction
Solubilization of mefenamic acid. Int J Pharm Tech.
- Chemical Industry Press;
- Mefenamic acid is also used to treat menstrual pain.
- If you have asthma or any other allergic disorder.
- If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.
- If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.
- Taking certain products together can cause you to get too much of this type of medication.
Tropical J Pharm Res. The effects of surfactants on the dissolution profiles of poorly water-soluble acidic drugs.
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